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Updated: Feb 9, 2026

Analysis of Electrocardiograms and Behavior in Mice from Pregnancy to Lactation Period
Published on: April 5, 2024
[PHYSICAL AND BEHAVIORAL DEVELOPMENT OF THE OFFSPRING OF FEMALE RATS TREATED WITH AFOBAZOLE DURING PREGNANCY.]
Afobazole did not harm organogenesis or fetal development in rats. While some temporary delays in weight gain and activity were observed, offspring fully recovered and met developmental standards by two months.
Area of Science:
- Pharmacology
- Developmental Toxicology
Background:
- Afobazole is a medication with anxiolytic properties.
- Assessing the safety of medications during pregnancy and early development is crucial.
Purpose of the Study:
- To evaluate the effects of afobazole on organogenesis and postnatal development in rat offspring.
- To determine if afobazole exposure impacts fetal development and long-term health.
Main Methods:
- Rats were administered afobazole during gestation and lactation.
- Offspring development was monitored for organogenesis, body weight, muscular force, locomotive activity, and sexual maturation.
- Postnatal development and physical maturation were assessed at various time points.
Main Results:
- Afobazole demonstrated no adverse effects on organogenesis or fetal development.
- Lactating rat pups exposed to afobazole showed transient reductions in body weight gain, muscular force, and locomotive activity.
- Sexual development was delayed in female offspring, but normalized by two months of age.
- Post-weaning, body weight gain and behavioral activity in offspring normalized, indicating no lasting detrimental effects.
Conclusions:
- Afobazole does not appear to cause teratogenic or fetotoxic effects.
- Transient developmental delays observed in offspring are reversible and do not lead to long-term health issues.
- Afobazole can be considered safe concerning organogenesis and postnatal development in rats.
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