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Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery
Published on: September 12, 2015
Cholesterol is the main regulator of the carbon dioxide permeability of biological membranes
Mariela Arias-Hidalgo1, Samer Al-Samir1, Gerolf Gros1
1Institut für Molekular und Zellphysiologie, AG Vegetative Physiologie, Medizinische Hochschule Hannover, Hannover , Germany.
Abstract:
We present here a compilation of membrane CO2 permeabilities (Pco2) for various cell types from the literature. Pco2 values vary over more than two orders of magnitude. Relating Pco2 to the cholesterol content of the membranes shows that, with the exception of red blood cells, it is essentially membrane cholesterol that determines the value of Pco2. Thus, the observed strong modulation of Pco2 in the majority of membranes is caused by cholesterol rather than gas channels.
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