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Updated: Feb 9, 2026
Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
Published on: March 22, 2012
Invasive pulmonary aspergillosis secondary to microwave ablation: a multicenter retrospective study
Guanghui Huang1, Xin Ye1, Xia Yang1
1a Department of Oncology , Shandong Provincial Hospital Affiliated to Shandong University , Jinan, Shandong Province , China.
Purpose:
Invasive pulmonary aspergillosis (IPA) is a life-threatening complication of microwave ablation (MWA) during the treatment of primary or metastatic lung tumors. The purpose of this study was to investigate the clinical, radiological and demographic characteristics and treatment responses of patients with IPA after MWA.
Materials And Methods:
From January 2011 to January 2016, all patients who were treated by MWA of their lung tumors from six health institutions were enrolled in this study. Patients with IPA secondary to MWA were identified and retrospectively evaluated for predisposing factors, clinical treatment, and outcome.
Results:
The incidence of IPA secondary to lung MWA was 1.44% (23/1596). Of the 23 patients who developed IPA, six died as a consequence, resulting in a high mortality rate of 26.1%. Using computed tomography (CT), pulmonary cavitation was the most common finding and occurred in 87.0% (20/23) of the patients. Sudden massive hemoptysis was responsible for one-third of the deaths (2/6). Most patients (22/23) received voriconazole as an initial treatment, and six patients with huge cavities underwent intracavitary lavage. Finally, 17 patients (73.9%) achieved treatment success.
Conclusions:
Lung MWA may be an additional host risk factor for IPA, particularly in elderly patients with underlying diseases and in patients who have recently undergone chemotherapy. Early and accurate diagnosis of IPA after MWA is critical for patient prognosis. Voriconazole should be given as the first-line treatment as early as possible. Bronchial artery embolization or intracavitary lavage may be required in some patients.
Insights
Invasive pulmonary aspergillosis (IPA) is a serious risk after lung microwave ablation (MWA). Early diagnosis and voriconazole treatment are crucial for improving patient outcomes and reducing mortality.
Area of Science:
- Pulmonology
- Oncology
- Infectious Diseases
Background:
- Invasive pulmonary aspergillosis (IPA) is a severe complication following lung tumor treatment.
- Microwave ablation (MWA) is a therapeutic option for lung tumors, but carries risks.
Purpose of the Study:
- To investigate the clinical, radiological, and demographic characteristics of IPA post-MWA.
- To evaluate treatment responses in patients with IPA after lung MWA.
Main Methods:
- Retrospective evaluation of patients treated with MWA for lung tumors between 2011 and 2016.
- Identification and analysis of patients who developed secondary IPA.
Main Results:
- The incidence of IPA post-MWA was 1.44%, with a high mortality rate of 26.1%.
- Pulmonary cavitation (87.0%) was the most common CT finding; sudden massive hemoptysis caused 33.3% of deaths.
- Voriconazole was the primary treatment, with 73.9% achieving success; intracavitary lavage was used in severe cases.
Conclusions:
- Lung MWA may increase the risk of IPA, especially in elderly patients or those with recent chemotherapy.
- Prompt diagnosis and early voriconazole treatment are critical for IPA prognosis.
- Bronchial artery embolization or lavage may be necessary for select patients.
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