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Related Concept Videos

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Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Related Experiment Video

Updated: Feb 9, 2026

Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time
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How to obtain informed consent for research.

Sara Manti1, Amelia Licari2

  • 1University of Messina, "G. Martino" Hospital, Messina, Italy.

Breathe (Sheffield, England)
|June 8, 2018
PubMed
Summary

Obtaining informed consent for clinical trials is strictly regulated. Challenges emerge when consent is waived or required from vulnerable populations, impacting ethical research practices.

Area of Science:

  • Bioethics
  • Clinical Research Regulations

Background:

  • Informed consent is a cornerstone of ethical clinical research.
  • Regulatory frameworks govern the informed consent process for clinical trials.

Purpose of the Study:

  • To examine the complexities and challenges in obtaining informed consent for clinical trials.
  • To identify circumstances where informed consent procedures require special consideration, such as waivers or vulnerable populations.

Main Methods:

  • Review of existing regulations and ethical guidelines pertaining to informed consent in clinical trials.
  • Analysis of case studies and literature addressing consent challenges in specific populations.

Main Results:

  • The process of informed consent is subject to stringent regulatory oversight.

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  • Complications frequently arise in situations necessitating consent waivers or involving vulnerable participant groups.

    • Conclusions:

    • Navigating informed consent in clinical trials requires careful adherence to regulations.
    • Special attention and ethical considerations are paramount when dealing with consent waivers and vulnerable populations.