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Updated: Feb 9, 2026

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications
Published on: April 13, 2022
A catalyst-free, temperature controlled gelation system for in-mold fabrication of microgels
Andreas J D Krüger1, Jens Köhler, Stefan Cichosz
1DWI-Leibniz-Institute for Interactive Materials, 52074 Aachen, Germany. delaporte@dwi.rwth-aachen.de.
Abstract:
Anisometric microgels are prepared via thermal crosslinking using an in-mold polymerization technique. Star-shaped poly(ethylene oxide-stat-propylene oxide) polymers, end-modified with amine and epoxy groups, form hydrogels, of which the mechanical properties and gelation rate can be adjusted by the temperature, duration of heating, and polymer concentration. Depending on the microgel stiffness, the rod-shaped microgels self-assemble into ordered or disordered structures.
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