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Published on: March 20, 2020
Immunotherapy in Breast Cancer: the New Frontier
Zishuo I Hu1, Heather L McArthur2
11Mount Sinai Health System, Icahn School of Medicine, New York, NY USA.
Purpose Of Review:
This review summarizes current immunotherapies in breast cancer, with an emphasis on immune checkpoint inhibitors and vaccines.
Recent Findings:
Combination immunotherapy with checkpoint inhibitors and cytotoxic therapies have shown promising results. Active clinical trials are ongoing in both early stage and metastatic settings for triple negative, HER2+, and hormone-positive breast cancer patients.
Summary:
Ongoing challenges remain in defining biomarkers that predict response to immunotherapy, determining the optimal combination immunotherapies, and enhancing the immunogenicity of breast cancer subtypes.
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