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Celastrol as a pentacyclic triterpenoid with chemopreventive properties

Priya Yadav1, Vishal Jaswal2, Ajay Sharma2

  • 1Department of Biotechnology, Maharishi Markandeshwar University, Mullana-Ambala, Haryana 133207, India.

Pharmaceutical Patent Analyst
|June 9, 2018
PubMed

Insights

Celastrol, a pentacyclic triterpenoid, shows anticancer potential by targeting multiple proteins involved in inflammation, angiogenesis, and metastasis. This review covers its molecular targets and recent patents (2011-2017).

Area of Science:

  • Natural Products Chemistry
  • Cancer Biology
  • Pharmacology

Background:

  • Celastrol is a pentacyclic triterpenoid with a long history of investigation for its therapeutic potential.
  • It has demonstrated promising chemopreventive properties.
  • Celastrol acts on multiple cellular pathways relevant to cancer development.

Purpose of the Study:

  • To review the diverse molecular targets of Celastrol.
  • To provide insights into recent (2011-2017) clinical, preclinical, and industrial patents related to Celastrol.
  • To consolidate current knowledge on Celastrol's anticancer mechanisms.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of patent databases (clinical, preclinical, industrial) from 2011-2017.
  • Synthesis of information on Celastrol's molecular targets and therapeutic applications.

Main Results:

  • Celastrol targets multiple proteins implicated in inflammation, angiogenesis, and metastasis.
  • Inhibition of these targets leads to reduced cancer growth, survival, and metastasis.
  • A significant number of patents highlight ongoing research and development in Celastrol-based cancer therapies.

Conclusions:

  • Celastrol is a multifaceted anticancer agent with broad molecular targeting capabilities.
  • Recent patents underscore the continued interest and progress in leveraging Celastrol for cancer treatment.
  • Further research into Celastrol's mechanisms and clinical applications is warranted.
Keywords:
anti-inflammationantiangiogenesisanticancerantimetastasisantioxidantcelastrolpatents

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