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Updated: Feb 9, 2026

In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation
Published on: November 11, 2025
Dry Eye Assessment and Management (DREAM©) Study: Study design and baseline characteristics
Penny A Asbell1, Maureen G Maguire2, Ellen Peskin2
1Icahn School of Medicine at Mount Sinai, Department of Ophthalmology, 1468 Madison Ave, Box 1183, New York, NY 10029, United States.
Purpose:
Describe trial design and baseline characteristics of participants in the DRy Eye Assessment and Management (DREAM©) Study.
Design:
Prospective, multi-center, randomized, double-masked "real-world" clinical trial assessing efficacy and safety of oral omega-3 (ω3) supplementation for the treatment of dry eye disease (DED).
Methods:
RESULTS: Mean age of participants was 58.0 ± 13.2 years. Mean OSDI score at baseline was 44.4 ± 14.2. Mean conjunctival staining score (scale 0-6) was 3.0 ± 1.4, corneal staining score (scale 0-15) was 3.9 ± 2.7, tear break-up time was 3.1 ± 1.5 s, and Schirmer test was 9.6 ± 6.5 mm/5 min.
Conclusions:
DREAM© participants mirror real world patients who seek intervention for their DED-related symptoms despite their current treatments. Results regarding the efficacy of omega-3 supplementation will be helpful to clinicians and patients with moderate to severe DED who are considering omega-3 as a treatment. This trial design may be a model for future RCT's on nutritional supplements and DED treatments seeking to provide useful information for clinical practice.
Trial Registration:
ClinicalTrials.gov number NCT02128763.
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