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Related Experiment Video

Updated: Feb 9, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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Aortic root dynamism, geometry, and function after the remodeling operation: Clinical relevance.

Magdi H Yacoub1, Heba Aguib2, Mazen Abou Gamrah3

  • 1Department of Surgery, Aswan Heart Centre, Cairo, Egypt; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Harefield Heart Science Centre, Harefield, Middlesex, United Kingdom.

The Journal of Thoracic and Cardiovascular Surgery
|June 10, 2018
PubMed
Summary

Valve-sparing aortic root repair normalizes aortic root geometry and maintains dynamic function, improving blood flow patterns. Further studies are needed to confirm long-term outcomes of this ascending aorta aneurysm treatment.

Keywords:
Yacoub operationaortic root dynamismaortic root replacementascending root aneurysmcomputational fluid dynamicsremodelingvalve-sparing

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Area of Science:

  • Cardiovascular Surgery
  • Medical Imaging
  • Biomechanical Engineering

Background:

  • Valve-sparing operations for ascending aorta and aortic root aneurysms are increasingly used.
  • Optimizing these procedures requires ensuring normal function and durability of the aortic root.

Purpose of the Study:

  • To evaluate the geometric and functional outcomes of valve-sparing aortic root repair.
  • To assess the impact of the remodeling operation on aortic root dynamics and blood flow.

Main Methods:

  • Utilized multimodality imaging (2D echocardiography, CT, MRI) and computational fluid dynamics.
  • Defined aortic root geometry, dynamism, and function before and after surgery.
  • Compared postoperative results with age-matched controls.

Main Results:

  • Postoperative aortic root and ascending aorta showed significant geometric changes with preserved dynamism.
  • Aortic annulus size decreased without external support, maintaining its elliptical shape and cyclic area changes.
  • Functional analysis confirmed preserved aortic root reservoir function and normalized flow patterns.

Conclusions:

  • The remodeling operation achieves near-normal aortic root geometry and maintains dynamic function.
  • These findings suggest significant functional implications for valve-sparing aortic root repair.
  • Further research is essential to determine the early- and long-term clinical outcomes.