Related Experiment Video

Updated: Feb 9, 2026

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
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Published on: May 2, 2017

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Pitfall of 18F-FDG PET/CT in Characterization of Relapsed Multisystem Lymphomatoid Granulomatosis

Kelly Tung1, Allison C Rosenthal2, Fiona E Craig3

  • 1Department of Radiology, Mayo Clinic Arizona, Scottsdale, Arizona.

Journal of Nuclear Medicine Technology
|June 10, 2018
PubMed

Insights

Serial 18F-FDG PET/CT imaging revealed transient response and multisystem recurrence of pulmonary lymphomatoid granulomatosis. Recurrence grading was limited by diverse histopathology despite imaging findings.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Pathology

Background:

  • Lymphomatoid granulomatosis (LYG) is a rare lymphoproliferative disorder.
  • Pulmonary involvement is common, and Epstein-Barr virus (EBV) positivity is associated with poorer prognosis.
  • Accurate staging and monitoring are crucial for treatment planning.

Observation:

  • A case of EBV-positive, grade 3 pulmonary LYG treated with R-CHOP chemotherapy is presented.
  • Serial 18F-FDG PET/CT demonstrated an initial complete response followed by multisystem recurrence, predominantly in the subcutaneous torso.
  • Biopsy of subcutaneous lesions revealed EBV-negative, grade 1 cutaneous LYG.

Findings:

  • 18F-FDG PET/CT effectively monitored treatment response and identified disease recurrence.
  • Discordance between PET/CT findings and histopathology in recurrence grading was observed.
  • EBV status changed from positive in pulmonary LYG to negative in cutaneous recurrence.

Implications:

  • 18F-FDG PET/CT is valuable for assessing LYG treatment response and detecting recurrence.
  • Limitations exist in differentiating LYG grades and subtypes based solely on 18F-FDG PET/CT.
  • The heterogeneity of LYG necessitates integrated clinical, imaging, and histopathological evaluation.
Keywords:
18F-FDGPET/CThematologylunglymphomalymphomatoid granulomatosis

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