Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Milgram's Obedience to Authority02:20

Milgram's Obedience to Authority

7.4K
Obedience to authority is classically demonstrated in a more famous series of social psychology experiments performed by Stanley Milgram. He was a social psychology professor at Yale who was influenced by the trial of Adolf Eichmann, a Nazi war criminal. Eichmann’s defense for the atrocities he committed was that he was “just following orders.”
7.4K
Lineage Commitment01:21

Lineage Commitment

4.4K
Commitment is the  process whereby stem cells:
4.4K
Distance Corrections01:15

Distance Corrections

297
To achieve precise distance measurements, especially in surveying and construction, certain corrections must be applied to account for potential sources of error like the standardization errors, temperature variations, and slope adjustments.Standardization error emerges when measurement equipment undergoes changes, such as wear, repairs, or weather impacts. To address this, surveyors compare the equipment’s readings to a standard. This process identifies any deviation that might lead to...
297
Power Factor Correction01:20

Power Factor Correction

547
The power transmission to a factory involves the transfer of apparent power, a combination of active and reactive power. The power factor measures how effectively electrical power is converted into useful work output. The ratio of the real power (KW) that does the work to the apparent power (KVA) supplied to the circuit.
547
Viral Recombination00:57

Viral Recombination

25.2K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
25.2K
Viral Structure00:56

Viral Structure

74.7K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
74.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Potent Inhibitor of Human Cytomegalovirus Infection Works Post-Entry Specifically in Differentiating Myelo-Monocytic Cells.

Pathogens (Basel, Switzerland)·2026
Same author

Cell Biology of Human Cytomegalovirus Latency: Implications for Pathogenesis and Treatment.

Reviews in medical virology·2025
Same author

The Triterpenoid MOMORDIN-Ic Inhibits HCMV by Preventing the Initiation of Gene Expression in Eukaryotic Cells.

Pathogens (Basel, Switzerland)·2024
Same author

A temperature-dependent virus-binding assay reveals the presence of neutralizing antibodies in human cytomegalovirus gB vaccine recipients' sera.

The Journal of general virology·2023
Same author

HCMV carriage in the elderly diminishes anti-viral functionality of the adaptive immune response resulting in virus replication at peripheral sites.

Frontiers in immunology·2023
Same author

Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spike.

EMBO reports·2022
Same journal

Non-canonical gene amplifications facilitate adaptive evolution in bacteria.

Nature microbiology·2026
Same journal

Identification of genetic markers of quinine partial resistance in Plasmodium falciparum.

Nature microbiology·2026
Same journal

The penicillin-binding protein PBP1b fortifies the Escherichia coli division site against osmotic rupture.

Nature microbiology·2026
Same journal

Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning.

Nature microbiology·2026
Same journal

Author Correction: Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids.

Nature microbiology·2026
Same journal

Mobile genetic elements shape microbial diversity and functions in thawing permafrost soils.

Nature microbiology·2026
See all related articles

Related Experiment Video

Updated: Feb 9, 2026

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
12:03

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

19.3K

Author Correction: Viral programming of progenitor cell commitment.

Matthew B Reeves1

  • 1UCL Institute of Immunity & Transplantation, Royal Free Hospital, London, UK. matthew.reeves@ucl.ac.uk.

Nature Microbiology
|June 10, 2018
PubMed
Summary
This summary is machine-generated.

Targeting latent US28 expression with immunotoxins can eliminate infected cells. This proof of concept study demonstrates a potential strategy for controlling viral infections.

More Related Videos

Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow
07:21

Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow

Published on: July 29, 2018

9.5K
Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development
14:08

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Published on: January 26, 2013

15.8K

Related Experiment Videos

Last Updated: Feb 9, 2026

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
12:03

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

19.3K
Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow
07:21

Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow

Published on: July 29, 2018

9.5K
Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development
14:08

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Published on: January 26, 2013

15.8K

Area of Science:

  • Virology
  • Immunology
  • Cell Biology

Context:

  • Human cytomegalovirus (HCMV) latency is a significant challenge in managing viral infections.
  • The US28 protein is a key viral gene product expressed during HCMV latency.
  • Targeting latently expressed viral proteins is a crucial area of research for developing novel antiviral therapies.

Purpose:

  • To investigate the efficacy of targeting latently expressed US28 using an immunotoxin-based approach.
  • To demonstrate the potential of eliminating latently infected cells in vitro.

Summary:

  • A proof of concept study successfully targeted latently expressed US28, a protein from human cytomegalovirus.
  • An immunotoxin-based strategy was employed to eliminate cells exhibiting latent US28 expression.
  • The findings indicate that targeting latent viral proteins is a viable strategy.

Impact:

  • This research opens new avenues for developing targeted therapies against latent viral infections.
  • The study provides a foundation for future in vivo investigations of immunotoxin efficacy.
  • Successful elimination of latently infected cells could lead to improved patient outcomes and reduced viral persistence.