Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

11.8K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
11.8K
Nose and Nasal Cavity01:24

Nose and Nasal Cavity

12.1K
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
12.1K
Internal Receptors01:31

Internal Receptors

74.7K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.7K
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

111.1K
Overview
111.1K
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

86.7K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
86.7K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

132.1K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
132.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The relationship between perceived stress and family quality of life: moderating impact of resilience among family caregivers of individuals with Parkinson's disease.

Clinical parkinsonism & related disorders·2026
Same author

Functional Nanovesicle-Embedded Hydrogel Biosensors for the Real-Time Monitoring of Queen Mandibular Pheromone in Both Aqueous and Gaseous Environments.

ACS applied materials & interfaces·2026
Same author

Urine-Based Noninvasive Detection of Prostate Cancer Using Human Olfactory Receptor-Embedded Nanodiscs.

ACS sensors·2026
Same author

Investigation of Physiological Responses of Different Soybean Cultivars Under Drought Stress.

Plants (Basel, Switzerland)·2026
Same author

Direct Mapping of Crystallization-Induced Trap-State Modulation and Its Impact on Local Carrier Mobilities in Indium Oxide Thin-Film Transistors.

Nano letters·2026
Same author

Direct Diagnosis of Chalkbrood Disease by Smelling Infected Honey Bee Larvae via Bioelectronic Noses with a Single-Carbon-Atomic Resolution.

ACS applied materials & interfaces·2026
Same journal

Tracking Synthetic Adhesins on Bacterial Surfaces with Immunofluorescence Microscopy.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Post-Selection Methods for Analyzing mRNA Display Selections and Optimization of Hits.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

High-Performance Computing in Tandem Mass Spectrometry (MS/MS) Peptide Identification.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Engineering and Adapting Disulfide-Containing Proteins to Enable Intracellular Functionality.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

AI-Driven Protein Research: From Prediction to Design.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Methods for the In Vitro Selection of Protein and Peptide Libraries Using mRNA Display.

Methods in molecular biology (Clifton, N.J.)·2026
See all related articles

Related Experiment Video

Updated: Feb 9, 2026

Co-Translational Insertion of Membrane Proteins into Preformed Nanodiscs
08:24

Co-Translational Insertion of Membrane Proteins into Preformed Nanodiscs

Published on: November 19, 2020

3.9K

Bioelectronic Nose Using Olfactory Receptor-Embedded Nanodiscs.

Heehong Yang1, Minju Lee2, Daesan Kim3

  • 1School of Chemical and Biological Engineering, Seoul National University, Seoul, South Korea.

Methods in Molecular Biology (Clifton, N.J.)
|June 10, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed a stable bioelectronic nose using olfactory receptors (ORs) embedded in nanodiscs. This novel biosensor platform demonstrates high sensitivity and selectivity for practical applications in disease diagnosis and product development.

Keywords:
Bioelectronic noseCarbon nanotubeField-effect transistorNanodiscOlfactory receptor

More Related Videos

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity
12:02

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity

Published on: June 2, 2014

13.0K
Whole Mount Immunolabeling of Olfactory Receptor Neurons in the Drosophila Antenna
05:21

Whole Mount Immunolabeling of Olfactory Receptor Neurons in the Drosophila Antenna

Published on: May 4, 2014

9.6K

Related Experiment Videos

Last Updated: Feb 9, 2026

Co-Translational Insertion of Membrane Proteins into Preformed Nanodiscs
08:24

Co-Translational Insertion of Membrane Proteins into Preformed Nanodiscs

Published on: November 19, 2020

3.9K
High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity
12:02

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity

Published on: June 2, 2014

13.0K
Whole Mount Immunolabeling of Olfactory Receptor Neurons in the Drosophila Antenna
05:21

Whole Mount Immunolabeling of Olfactory Receptor Neurons in the Drosophila Antenna

Published on: May 4, 2014

9.6K

Area of Science:

  • Biotechnology
  • Nanotechnology
  • Biosensor Development

Background:

  • Olfactory receptors (ORs) are a large family of G protein-coupled receptors (GPCRs) implicated in human diseases and drug discovery.
  • Developing stable biosensors using GPCRs remains a significant challenge for various applications.

Purpose of the Study:

  • To develop a stable and high-performance bioelectronic nose using OR-embedded nanodiscs.
  • To create a practical receptor-based sensing platform for diverse applications.

Main Methods:

  • Olfactory receptors (ORs) were produced in Escherichia coli (E. coli) and purified.
  • Purified ORs were reconstituted into nanodiscs.
  • OR-embedded nanodiscs were integrated with a carbon nanotube-field effect transistor (CNT-FET).

Main Results:

  • The nanodisc-based bioelectronic nose demonstrated high sensitivity, selectivity, and stability.
  • The developed platform shows potential for practical biosensing applications.

Conclusions:

  • The OR-embedded nanodisc strategy offers a promising approach for creating advanced bioelectronic noses.
  • This advancement represents significant progress in nano-bio technology for practical biosensor development.