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From Atoms to Cells: Using Mesoscale Landscapes to Construct Visual Narratives
David S Goodsell1, Margaret A Franzen2, Tim Herman2
1Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; RCSB Protein Data Bank & Center for Integrative Proteomics Research, Rutgers State University, Piscataway, NJ 08854, USA.
Journal of Molecular Biology
|June 10, 2018
Summary
Researchers are modeling cellular mesoscale dynamics by integrating diverse biological data. This approach creates visual cellular landscapes for scientific discovery and education.
Area of Science:
- Cellular biology
- Structural biology
- Computational biology
Background:
- Understanding cellular processes requires bridging molecular and cellular scales.
- Current models often lack integration of diverse data types.
Purpose of the Study:
- To develop an integrative approach for modeling and visualizing the cellular mesoscale.
- To create dynamic cellular landscapes as research tools.
Main Methods:
- Integrating data from structural biology, proteomics, and microscopy.
- Simulating the molecular structure of living cells.
Main Results:
- Development of a computational framework for cellular mesoscale modeling.
- Generation of visual cellular landscapes representing molecular organization.
Conclusions:
- The integrative approach enables novel insights into cellular function.
- Visual cellular landscapes serve as valuable tools for research, education, and outreach.
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