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Updated: Feb 9, 2026

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
Published on: September 14, 2014
CD4-HIV-1 Envelope Interactions: Critical Insights for the Simian/HIV/Macaque Model
Amit Sharma1,2, Julie Overbaugh1
11 Division of Human Biology, Fred Hutchinson Cancer Research Center , Seattle, Washington.
Abstract:
The macaque models of HIV-1 infection have been a cornerstone of research on transmission, pathogenesis, and prevention. In particular, the infection of macaques with chimeric simian/HIV-1 viruses (SHIVs) is central to the vaccine development pipeline because SHIVs encode the key target of HIV-1-neutralizing antibodies, the HIV-1 envelope (env) protein. In this review, we highlight some of the recent studies that have improved our understanding of the CD4-HIV-1 env interaction, which are crucial for development of SHIV/macaque models of HIV-1 infection.
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