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Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

Vaccination strategies.

Thomas Wisniewski¹, Fernando Goñi²

¹Center for Cognitive Neurology, New York University School of Medicine, New York, NY, United States; Department of Neurology, New York University School of Medicine, New York, NY, United States; Department of Pathology, New York University School of Medicine, New York, NY, United States; Department of Psychiatry, New York University School of Medicine, New York, NY, United States.

Handbook of Clinical Neurology

|June 12, 2018

Summary

This summary is machine-generated.

Developing immunotherapies, including mucosal vaccines, offers a promising avenue for treating fatal prion diseases. These approaches may also benefit other neurodegenerative conditions like Alzheimer disease.

Keywords:

Creutzfeldt–Jakob disease bovine spongiform encephalopathy chronic wasting disease immunomodulation mucosal immunization prion disease vaccine

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Area of Science:

Neuroscience
Immunology
Infectious Diseases

Background:

Prion diseases are fatal neurodegenerative disorders with no effective treatments.
Prion-like mechanisms are implicated in other neurodegenerative diseases, such as Alzheimer disease (AD).
Therapeutic strategies for AD may offer insights for prion disease treatment and vice versa.

Purpose of the Study:

To review current immunologically based strategies for prion infection.
To explore the potential of immunotherapies, particularly mucosal vaccination, for prion disease.
To highlight the implications of prion disease therapies for other neurodegenerative conditions.

Main Methods:

Review of experimental data on immunotherapies for prion models and naturally occurring prion disease.
Focus on mucosal vaccination strategies for orally acquired prion infections.
Examination of ongoing clinical trials for Alzheimer disease immunotherapies.

Main Results:

Vaccine and immunomodulatory approaches show success in animal models of AD.
Limited evidence suggests immunotherapy efficacy in prion models and natural prion disease.
Mucosal vaccination demonstrates potential for protection against oral prion exposure.

Conclusions:

Immunotherapy, especially mucosal vaccination, represents a potential therapeutic strategy for prion diseases.
Effective prion disease treatments could have significant implications for Alzheimer disease and other neurodegenerative disorders.
Further research into immunologically based strategies is crucial for developing effective prion disease therapies.