Related Experiment Video

Updated: Feb 9, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.3K

Numerical simulation study on systolic anterior motion of the mitral valve in hypertrophic obstructive cardiomyopathy

Long Deng1, Xueying Huang2, Chun Yang3

  • 1Department of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

International Journal of Cardiology
|June 12, 2018
PubMed

Insights

Systolic anterior motion (SAM) in hypertrophic obstructive cardiomyopathy (HOCM) is initiated by high pressure and shear stress on mitral valve leaflets. Successful surgery increases distance, preventing SAM.

Area of Science:

  • Cardiovascular Physiology
  • Biomechanical Engineering
  • Medical Imaging

Background:

  • The underlying hydrodynamic mechanisms driving systolic anterior motion (SAM) of the mitral valve in hypertrophic obstructive cardiomyopathy (HOCM) are not fully understood.
  • Investigating these mechanisms is crucial for improving treatment strategies.

Purpose of the Study:

  • To elucidate the hydrodynamic forces and mechanical behaviors of the mitral valve associated with SAM in HOCM patients.
  • To evaluate the impact of septal myectomy on these factors and the resolution of SAM.

Main Methods:

  • Construction of pre- and post-operative computational fluid dynamics (CFD) and fluid-structure interaction (FSI) models of the left ventricle using CT images from 6 HOCM patients.
  • Comparison of simulation results, including left ventricular flow fields and mitral valve mechanics, before and after septal myectomy surgery.
  • Correlation of surgical outcomes (SAM abolished vs. persisted) with biomechanical parameters.

Main Results:

  • Pre-operative models showed elevated pressure differences and shear stress on mitral valve leaflets (MVL) in HOCM patients.
  • These stresses significantly decreased after successful septal myectomy but remained high after unsuccessful surgery.
  • A significant increase in coaptation-to-septal distance was observed in patients where SAM was abolished.

Conclusions:

  • High pressure differences and shear stress on the MVL are likely direct initiators of SAM in HOCM.
  • Effective septal myectomy surgery increases the coaptation-to-septal distance, moving the MVL away from obstructive ejection flow and thereby eliminating SAM.
Abstract

Keywords:
Computational modelHypertrophic obstructive cardiomyopathyNumerical simulationSeptal myectomySystolic anterior motion

More Related Videos

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat07:42

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Published on: May 19, 2020

7.5K
Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

13.4K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
509
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
570
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
630
Mitral Valve Prolapse III: Nursing Management01:19

Mitral Valve Prolapse III: Nursing Management

The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
395
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
575
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
575