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Updated: Feb 9, 2026
08:31
Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro
Published on: November 26, 2018
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Heterogeneity of Memory Marginal Zone B Cells
Jacobus Hendricks1,2, Nicolaas A Bos1, Frans G M Kroese1
1Discipline of Human Physiology, Westville Campus, University of KwaZulu-Natal, Durban, South Africa.
Critical Reviews in Immunology
|June 12, 2018
Summary
Splenic marginal zone (MZ) B cells in rats include both naive and memory cells. Memory MZ-B cells, though a minor fraction, possess mutated genes and high-affinity antibodies, crucial for adaptive immunity.
Area of Science:
- Immunology
- Cell Biology
Background:
- The marginal zone (MZ) of the spleen hosts a unique population of B cells, known as MZ-B cells.
- Memory B cells are molecularly defined by somatically mutated immunoglobulin variable (IGV) genes.
- Previous studies in rats indicated hapten-specific MZ-B cells post-immunization.
Purpose of the Study:
- To investigate the memory compartment of splenic MZ-B cells in rats.
- To elucidate the origin and function of these memory MZ-B cells.
Main Methods:
- Phenotypic definition of splenic MZ-B cells (CD90negIgMhighIgDlow).
- Analysis of immunoglobulin heavy variable (IGHV)-Cµ transcripts for somatic hypermutation.
- Characterization of B cell heterogeneity within the splenic MZ.
Main Results:
- A minor fraction (<10%-20%) of splenic MZ-B cells exhibit somatic hypermutation, identifying them as memory B cells.
- Splenic MZ contains both naive MZ-B cells with unmutated genes and memory MZ-B cells (class-switched and unswitched).
- Naive MZ-B cells produce low-affinity IgM and act as a first line of defense, while memory MZ-B cells produce high-affinity antibodies.
Conclusions:
- Splenic MZ-B cells are a heterogeneous population comprising naive and memory subsets.
- Memory MZ-B cells are critical for mounting rapid and high-affinity immune responses upon re-encountering antigens.
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