Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

266
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
266
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

320
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
320
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

239
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
239
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

305
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
305
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.1K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.1K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.4K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physiological responses to retinopathy of prematurity screening: indirect ophthalmoscopy versus ultra-widefield retinal imaging.

Pediatric research·2025
Same author

Visual Improvement Despite Macular Pucker After Inverted Internal Limiting Membrane Flap Technique for Idiopathic Macular Hole.

Journal of vitreoretinal diseases·2024
Same author

Simulating retinopathy of prematurity (ROP) indirect laser treatment using ultra-wide-field images in model eyes.

Eye (London, England)·2023
Same author

New method to measure interbreath intervals in infants for the assessment of apnoea and respiration.

BMJ open respiratory research·2021
Same author

Ectopic vortex veins and varices in Donnai Barrow syndrome.

Ophthalmic genetics·2021
Same author

Evolving outcomes of surgery for retinal detachment in retinopathy of prematurity: the need for a national service in the United Kingdom : An audit of surgery for acute tractional retinal detachment complicating ROP in the UK.

Eye (London, England)·2021

Related Experiment Video

Updated: Feb 9, 2026

Using Adeno-associated Virus as a Tool to Study Retinal Barriers in Disease
10:14

Using Adeno-associated Virus as a Tool to Study Retinal Barriers in Disease

Published on: April 19, 2015

15.6K

Ultra-Widefield Imaging for Pediatric Retinal Disease.

Chetan Kantibhai Patel1, Miranda Buckle2

  • 1Oxford Eye Hospital, Oxford, England.

Asia-Pacific Journal of Ophthalmology (Philadelphia, Pa.)
|June 12, 2018
PubMed
Summary

This article discusses advancements in retinal imaging, focusing on ultra-widefield technology and its field of view. It details Optomap and Spectralis systems for infant angiography and showcases applications in diagnosis, monitoring, and screening.

Keywords:
retinal imagingretinal oximetryretinopathy of prematuritywide-field imaging

More Related Videos

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

22.3K
Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
07:22

Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases

Published on: March 11, 2016

11.9K

Related Experiment Videos

Last Updated: Feb 9, 2026

Using Adeno-associated Virus as a Tool to Study Retinal Barriers in Disease
10:14

Using Adeno-associated Virus as a Tool to Study Retinal Barriers in Disease

Published on: April 19, 2015

15.6K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

22.3K
Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
07:22

Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases

Published on: March 11, 2016

11.9K

Area of Science:

  • Ophthalmology
  • Medical Imaging

Background:

  • Retinal imaging is crucial for diagnosing and monitoring eye conditions.
  • Traditional imaging methods have limitations in capturing the peripheral retina.

Purpose of the Study:

  • To explore the development and applications of ultra-widefield retinal imaging.
  • To detail specific ultra-widefield platforms like Optomap and Spectralis.

Main Methods:

  • Review of ultra-widefield imaging technology and its principles.
  • Detailed examination of Optomap and Spectralis noncontact imaging systems.
  • Inclusion of protocols for infant angiography.

Main Results:

  • Ultra-widefield imaging significantly expands the field of view compared to traditional methods.
  • Optomap and Spectralis offer advanced capabilities for retinal visualization.
  • Case studies demonstrate effective use in diagnosis, monitoring, and screening.

Conclusions:

  • Ultra-widefield imaging represents a significant advancement in ophthalmology.
  • These technologies enhance the ability to detect and manage peripheral retinal diseases.
  • The platforms are valuable tools for both routine care and specialized infant diagnostics.