Related Experiment Video
Updated: Feb 9, 2026
Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
The Relationship Between Aspirin Resistance and Carotid Imaging in Young Patients With ST-Segment Elevated Myocardial
Mustafa Umut Somuncu1, Ali Riza Demir2, Huseyin Karakurt2
11 Department of Cardiology, Bulent Ecevit University Faculty of Medicine, Zonguldak, Turkey.
Insights
Aspirin resistance (AR) affects 30.3% of young patients with ST-segment elevated myocardial infarction (STEMI). High-risk carotid images, including plaque and thicker intima-media, are linked to increased odds of AR.
Area of Science:
- Cardiology
- Vascular Biology
- Platelet Physiology
Background:
- Carotid atherosclerosis and coronary artery disease predict poor cardiovascular outcomes.
- A subset of patients on aspirin experience recurrent cardiovascular events, potentially due to aspirin resistance (AR).
- Turbulent blood flow from carotid plaques may activate platelets, leading to inadequate response to antiplatelet therapy.
Purpose of the Study:
- To determine the prevalence of aspirin resistance (AR) in young patients with ST-segment elevated myocardial infarction (STEMI).
- To investigate the association between high-risk carotid imaging findings and AR in this patient group.
Main Methods:
- 112 patients under 45 years with STEMI were included.
- Aspirin response was assessed 1 hour post-aspirin intake using a multiplate platelet function analyzer.
- Carotid ultrasonography evaluated carotid intima-media thickness (CIMT) and identified carotid plaques.
Main Results:
- Aspirin resistance (AR) was identified in 30.3% of young STEMI patients.
- Patients with AR showed significantly higher CIMT (P = .002), presence of carotid plaque (P = .012), and high-risk carotid imaging (P = .015).
- Carotid plaque (OR 3.7) and high-risk carotid imaging (OR 3.2) were independently associated with increased odds of AR, irrespective of other risk factors.
Conclusions:
- Physicians should consider aspirin resistance (AR) in young STEMI patients.
- The presence of carotid plaque and increased CIMT are significant indicators for potential AR in this population.
- Targeted assessment for AR may be warranted in young STEMI patients with specific carotid imaging findings.
Abstract:
The presence of carotid atherosclerosis accompanied by coronary artery disease is associated with poor prognosis. A subset of patients who take aspirin continue to have recurrent cardiovascular events, which may be due to aspirin resistance (AR). Also, carotid plaques may cause turbulent flow which in turn may lead to platelet activation and poor antiplatelet response. In our study, we aimed to show the prevalence of AR and its relationship between high-risk carotid images in young patients with ST-segment elevated myocardial infarction (STEMI). In our study, we included 112 patients younger than 45 years with STEMI. Aspirin response test was evaluated 1 hour after aspirin intake using multiplate platelet function analyzer, and carotid ultrasonography has been performed to determine carotid intima-media thickness (CIMT) and the presence of carotid plaque. We identified 30.3% AR in young patients with STEMI. Carotid intima-media thickness ( P = .002), carotid plaque ( P = .012), and high-risk carotid image ( P = .015) values are significantly high in patients who have AR. Independent of other risk factors, the presence of carotid plaque and being in the high-risk carotid group were associated with 3.7 times and 3.2 times increased odds for AR, respectively. In young patients with STEMI, physicians should be careful about AR, especially in patients who have carotid plaque and thicker CIMT.
Related Concept Videos
01:50Cross-Sectional Research
01:24Finding Volume Using Cross-Sectional Area
01:26Profile Leveling and Cross Sections
01:16Spinal Cord: Cross-sectional Anatomy
Gray Matter and its Components
Central to the gray matter is...
01:34Crossing Over
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
03:12Freezing Point Depression and Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...