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Related Experiment Video

Updated: Feb 9, 2026

Author Spotlight: Exploring the Mysteries of Sichuan's Herbal Medicine in Chinese Medicine Research
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PATHOPHYSIOLOGICAL ASPECTS OF PLEIOTROPIC EFFECTS OF GASTROINTESTINAL HORMONES.

O V Korniushyn, J G Toropova, G V Semikova

    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
    |June 12, 2018
    PubMed
    Summary

    Incretin drugs, like glucagon-like peptide-1 (GLP-1), are vital for type 2 diabetes treatment. Research shows these gastrointestinal hormones have protective and growth-promoting effects, with ongoing studies into bariatric surgery

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    Area of Science:

    • Endocrinology and Metabolism
    • Gastroenterology

    Background:

    • Incretin-based therapies have rapidly become central to type 2 diabetes management due to their efficacy.
    • The discovery of the incretin effect has spurred research into the broader, pleiotropic actions of gastrointestinal hormones.
    • Intestinal hormones such as glucagon-like peptide-1 (GLP-1), ghrelin, and obestatin have demonstrated cytoprotective and cytoproliferative effects.

    Purpose of the Study:

    • To review current research on the pleiotropic effects of gastrointestinal peptides.
    • To analyze fundamental and clinical findings regarding these hormones.
    • To assess the significance of further investigation into the metabolic outcomes of bariatric surgery.

    Main Methods:

    • Systematic review of existing scientific literature.
    • Analysis of experimental and clinical study results.
    • Evaluation of data on gastrointestinal peptide administration and bariatric surgery outcomes.

    Main Results:

    • Incretin drugs, including GLP-1 mimetics, are established treatments for type 2 diabetes.
    • Gastrointestinal hormones exhibit significant cytoprotective and cytoproliferative properties.
    • Evidence suggests a growing interest in the systemic administration effects of these peptides.

    Conclusions:

    • Gastrointestinal peptides possess multifaceted therapeutic potential beyond glucose regulation.
    • Further research is warranted to fully elucidate the pleiotropic effects of these hormones.
    • Investigating the metabolic impact of bariatric surgery in relation to these peptides is relevant.