PATHOPHYSIOLOGICAL ASPECTS OF PLEIOTROPIC EFFECTS OF GASTROINTESTINAL HORMONES

The unique properties and a great therapeutic potential of incretin drugs allowed them to win a firm place in modern algorithms of treatment of type 2 diabetes in an unprecedented short period of time. Due to discovery of the incretin effect and introduction of the increrin mimetics into clinical practice, an interest of the researchers was growing to study the plelotropic effects of gastrointestinal hormones. In experimental and clinical studies in recent years there has been shown the cytoprotective and cytoproliferative effects of a number of intestinal hormones, namely giucagon-like peptide-1 (GLP-1), ghrelin, and obestatin when administered systemicallyThis review presents an analysis of the currently available results of fundamental and clinical research on the plelotropic potential of the gastrointestinal peptides, and also determines the relevance of further research on the metabolic effects of bariatric surgery.