Related Experiment Video
Updated: Feb 9, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
POST-GENOMIC MEDICINE: THE DIAGNOSTIC VALUE OF PROTEOMIC ANALYSIS IN PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE
Purpose:
Study the characteristics of proteomic profile of esophageal mucosa in different forms and gradations of gastro-esophageal reflux disease (GERD).
Materials And Methods:
The study included 68 patients with verified GERD. Studied the proteomic profile of a gullet a method of tandem time-of-flight MALDI mass spectrometry using bioinformation algorithms.
Results:
The identified proteins are involved in the regulation of inflammation, apoptosis, adhesion and transport of ions and other important biological processes. The data obtained allow to expand the understanding of the molecular mechanisms of this pathology development. Identified proteins in the esophagus can be used as informative markers of the complicated course of GERD.
Related Concept Videos
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Genomics
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History

