THE USE OF DEXMEDETOMIDINE IN COMBINATION NEFOPAM FOR POSTOPERATIVE ANALGESIA AFTER LAPAROSCOPIC CORRECTION OF MORBID...

Area of Science:

• Anesthesiology
• Pain Management
• Surgical Trauma

Background:

• Morbid obesity presents unique challenges in postoperative pain management after bariatric surgery.
• Optimizing analgesia while mitigating the inflammatory response is crucial for patient recovery.

Purpose of the Study:

• To evaluate the efficacy and safety of combining dexmedetomidine with nefopam for postoperative pain relief in patients undergoing bariatric surgery.
• To assess the impact of this combination on the inflammatory response following surgical trauma.

Main Methods:

• Prospective cohort study involving 48 patients with morbid obesity.
• Pain assessment using a numeric rating scale and monitoring of hemodynamic parameters.
• Evaluation of the inflammatory response, including Interleukin-6 (IL-6) levels.

Main Results:

• Dexmedetomidine and nefopam combination provided effective postoperative pain relief in bariatric surgery patients.
• This combination did not suppress the postoperative inflammatory response, unlike ketorolac tromethamine.
• The combination demonstrated a more rapid onset of analgesia compared to ketorolac tromethamine, with better control over IL-6 levels.

Conclusions:

• The combination of dexmedetomidine and nefopam is a viable option for achieving sufficient analgesia after bariatric surgery.
• This analgesic strategy preserves the normal inflammatory response, unlike ketorolac tromethamine.
• The dexmedetomidine-nefopam combination offers a faster onset of pain relief and better modulation of the inflammatory markers compared to ketorolac.