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Related Experiment Video

Updated: Feb 9, 2026

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
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Cerebellar involvement in autism and ADHD.

Muriel M K Bruchhage1, Maria-Pia Bucci2, Esther B E Becker3

  • 1Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Handbook of Clinical Neurology
|June 13, 2018
PubMed
Summary

The cerebellum, crucial for motor control, is increasingly linked to cognition and emotion. This review examines its role in autism spectrum disorder and attention deficit-hyperactivity disorder pathogenesis.

Keywords:
Purkinje cellattention deficit-hyperactivity disorderautism spectrum disorderbrain developmentcerebellummouse modelsneuroimagingposture

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Neurobiology

Background:

  • The cerebellum is traditionally associated with motor control and coordination.
  • Emerging evidence highlights the cerebellum's significant role in cognitive and emotional processing.
  • Cerebellar dysfunction is implicated in various nonmotor neurodevelopmental disorders.

Purpose of the Study:

  • To explore the cerebellum's contribution to the pathogenesis of autism spectrum disorder (ASD) and attention deficit-hyperactivity disorder (ADHD).
  • To synthesize findings from human and animal studies regarding cerebellar involvement in these disorders.

Main Methods:

  • Review of human studies including behavioral, postmortem, genetic, and neuroimaging data.
  • Inclusion of relevant findings from animal models of ASD and ADHD.

Main Results:

  • The cerebellum is implicated in the pathophysiology of both autism spectrum disorder and attention deficit-hyperactivity disorder.
  • Evidence suggests cerebellar alterations contribute to the nonmotor symptoms of these conditions.

Conclusions:

  • The cerebellum plays a critical role beyond motor function, influencing cognition and emotion.
  • Understanding cerebellar contributions is vital for developing targeted therapies for autism spectrum disorder and attention deficit-hyperactivity disorder.