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Updated: Feb 9, 2026
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Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
Published on: September 29, 2017
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Tunable chitosan hydrogels for adsorption: Property control by biobased modifiers
Zhaoxuan Feng1, Karin Odelius1, Minna Hakkarainen1
1Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Teknikringen 58, 100 44 Stockholm, Sweden.
Carbohydrate Polymers
|June 13, 2018
Summary
This study presents a sustainable chitosan-based hydrogel for removing pharmaceuticals. The composite hydrogel, modified with nano-graphene oxide (nGO) and genipin, effectively adsorbs diclofenac sodium (DCF) with tunable efficiency.
Area of Science:
- Materials Science
- Environmental Science
- Biotechnology
Background:
- Pharmaceutical pollution is a growing environmental concern.
- Developing efficient and sustainable adsorbents is crucial for wastewater treatment.
- Chitosan-based hydrogels offer potential due to their biocompatibility and tunable properties.
Purpose of the Study:
- To fabricate chitosan-based composite hydrogels with tunable properties.
- To investigate the influence of nano-graphene oxide (nGO) and genipin on hydrogel characteristics.
- To evaluate the hydrogel's efficacy in adsorbing trace pharmaceuticals, specifically diclofenac sodium (DCF).
Main Methods:
- Fabrication of chitosan-based hydrogels using genipin as a crosslinker.
- Incorporation of nano-graphene oxide (nGO) derived from chitosan.
- Characterization of hydrogel properties including crosslinking degree, swelling ratio, and surface microtopography.
- Assessment of hydrogel adsorption capacity for diclofenac sodium (DCF).
Main Results:
- Genipin content controlled the degree of crosslinking, affecting storage modulus and swelling ratio.
- nGO content modified surface microtopography and wettability, and catalyzed crosslinking.
- The composite hydrogel demonstrated high removal efficiency (91-100%) for DCF within 48 hours.
- Adsorption efficiency was tunable by adjusting nGO and genipin concentrations.
Conclusions:
- A sustainable chitosan-based composite hydrogel with tunable adsorption properties was successfully developed.
- The nGO-modified hydrogel is an effective and environmentally friendly adsorbent for diclofenac sodium removal.
- This approach shows significant potential for treating pharmaceutical wastewater.
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