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Related Experiment Video

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Phoenixin-A Pleiotropic Gut-Brain Peptide.

Martha A Schalla1, Andreas Stengel2,3

  • 1Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany. martha.schalla@charite.de.

International Journal of Molecular Sciences
|June 13, 2018
PubMed
Summary
This summary is machine-generated.

Phoenixin, a brain peptide, is now known to have diverse roles beyond reproduction. This review explores its functions in behavior, memory, and the cardiovascular system, revealing its widespread impact.

Keywords:
central nervous systemfood intakegastrointestinal tractgut hormonegut-brain axisneuropeptideorexigenicphoenixin-14phoenixin-20

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Area of Science:

  • Neuroendocrinology
  • Molecular Biology
  • Physiology

Background:

  • Phoenixin is a novel peptide initially identified in the brain.
  • Its functions were initially presumed to be limited to reproductive processes.
  • Recent findings indicate phoenixin expression in peripheral tissues.

Purpose of the Study:

  • To review current knowledge on phoenixin and its signaling pathways.
  • To highlight the pleiotropic effects of phoenixin.
  • To identify knowledge gaps and stimulate future research.

Main Methods:

  • Literature review of existing studies on phoenixin.
  • Analysis of reported phoenixin expression patterns.
  • Synthesis of data on phoenixin's diverse physiological effects.

Main Results:

  • Phoenixin exhibits a broader range of functions than previously understood.
  • Documented effects include impacts on behavior, sensory perception, memory, cardiovascular function, and food intake.
  • Phoenixin's expression is not restricted to the brain but occurs in peripheral tissues.

Conclusions:

  • Phoenixin plays a pleiotropic role, influencing multiple physiological systems.
  • Further research is needed to fully elucidate phoenixin signaling and its comprehensive functions.
  • Understanding phoenixin's multifaceted actions is crucial for future therapeutic strategies.