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Iron Therapy in Heart Failure: Ready for Primetime?
Ify R Mordi1, Aaron Tee1, Chim C Lang1
1Division of Molecular and Clinical Medicine, University of Dundee Dundee, UK.
Cardiac Failure Review
|June 13, 2018
Summary
Iron deficiency is common in heart failure patients, even without anemia, and impacts outcomes. Iron replacement therapy is being investigated to improve heart failure management.
Area of Science:
- Cardiology
- Hematology
Background:
- Iron deficiency (ID) is increasingly recognized in heart failure (HF) patients.
- ID contributes significantly to heart failure morbidity and mortality.
- Many heart failure patients have iron deficiency without anemia.
Purpose of the Study:
- To review the pathophysiology and epidemiology of iron deficiency in heart failure.
- To discuss the evidence supporting iron replacement therapy in heart failure.
- To highlight ongoing trials evaluating iron replacement in heart failure.
Main Methods:
- Literature review of pathophysiology and epidemiology of ID in HF.
- Analysis of existing evidence for iron replacement therapy efficacy.
- Summary of ongoing large outcome trials.
Main Results:
- Iron deficiency is prevalent in heart failure and linked to worse outcomes.
- Screening for iron deficiency is crucial, irrespective of hemoglobin levels.
- Evidence supports the investigation and use of iron replacement therapy.
Conclusions:
- Iron deficiency is a significant comorbidity in heart failure.
- Early screening and consideration of iron replacement are vital for managing heart failure patients.
- Ongoing trials will provide further insights into the role of iron in HF management.
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