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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Treatment of Hypertension in Chronic Kidney Disease

Rigas G Kalaitzidis1, Moses S Elisaf2

  • 1Department of Nephrology, University Hospital of Ioannina, 455 00, Ioannina, Greece. rigaska@gmail.com.

Current Hypertension Reports
|June 13, 2018
PubMed

Insights

Managing hypertension in chronic kidney disease (CKD) involves a blood pressure goal below 130/80 mmHg. Key treatments include ACE inhibitors, ARBs, and diuretics, with CCBs used cautiously.

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Chronic kidney disease (CKD) is a global health issue.
  • Hypertension is a common comorbidity that worsens with declining kidney function.

Purpose of the Study:

  • To review current treatment options for hypertension in CKD patients.
  • To highlight updated hypertension guidelines for CKD management.

Main Methods:

  • Review of current hypertension guidelines.
  • Analysis of antihypertensive medication classes for CKD patients.

Main Results:

  • Updated guidelines recommend a blood pressure goal < 130/80 mmHg for CKD patients.
  • Angiotensin-converting enzyme (ACE) inhibitors are first-line agents, with Angiotensin II receptor blockers (ARBs) as alternatives.
  • Non-dihydropyridine calcium channel blockers (CCBs) reduce albuminuria; dihydropyridine CCBs require combination therapy with RAAS blockers.

Conclusions:

  • Intensive blood pressure control is crucial for CKD patients.
  • A stepwise approach using ACE inhibitors/ARBs, diuretics, and CCBs is recommended.
  • Lifestyle modifications and pharmacotherapy are essential for managing hypertension in CKD.
Abstract

Keywords:
ACE inhibitorsAlbuminuriaAntihypertensive therapyChronic kidney diseaseHypertensionRAAS blockers

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