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Updated: Feb 9, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

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Initial experience of percutaneous left atrial appendage closure using the LAmbre device for thromboembolic

Nico Reinsch1,2, Ute Ruprecht1,3,2, Jochen Buchholz1

  • 1Department of Electrophysiology, Alfried Krupp Krankenhaus.

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|June 13, 2018
PubMed

Insights

The LAmbre device offers a new option for percutaneous left atrial appendage (LAA) closure in atrial fibrillation patients. Initial studies show successful implantation and good clinical outcomes, even in complex cases.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Devices

Background:

  • Atrial fibrillation (AF) poses a significant stroke risk, especially in patients ineligible for anticoagulation.
  • Percutaneous left atrial appendage (LAA) closure is an established stroke prevention strategy.
  • The LAmbre occluder is a novel device designed for adaptable LAA closure.

Purpose of the Study:

  • To assess the feasibility and initial clinical experience of LAA occlusion using the LAmbre device.
  • To evaluate the LAmbre occluder in a non-selected patient cohort.
  • To demonstrate the device's adaptability in various LAA anatomies.

Main Methods:

  • Implantation of the LAmbre occluder in 11 patients with nonvalvular AF.
  • Follow-up assessments at 6 weeks and 6 months, including transesophageal echocardiography.
  • Evaluation of procedural success and clinical outcomes.

Main Results:

  • Successful LAmbre device implantation in all 11 patients.
  • No deaths, strokes, systemic thromboembolism, or major bleeding occurred within 6 months.
  • Minimal peridevice flow (<5mm) was noted in one patient; no device-related thrombus or effusion observed.

Conclusions:

  • The LAmbre occluder is a feasible and effective novel device for LAA closure.
  • It offers versatile options for physicians, particularly for challenging LAA anatomies.
  • Initial experience indicates a good success rate and favorable clinical outcomes.
Abstract

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