Related Experiment Video
Updated: Feb 9, 2026
13:28
Introducing Shear Stress in the Study of Bacterial Adhesion
Published on: September 2, 2011
16.3K
Infection Retardant Coatings Impact on Bacterial Presence in Penile Prosthesis Surgery: A Multicenter Study
Kavina Jani1, Christopher Smith2, John R Delk3
1ArkLaTex Urology, Bossier City, LA.
Urology
|June 13, 2018
Summary
Infection retardant coatings (IRC) on penile prostheses (PPs) were associated with fewer positive bacterial cultures, particularly Staphylococcus, in noninfected patients undergoing revision surgery. IRC PPs showed a different bacterial profile in infected patients as well.
Area of Science:
- Urology
- Infectious Diseases
- Biomaterials Science
Background:
- Penile prostheses (PPs) are used to treat erectile dysfunction.
- Infection is a significant complication following PP implantation.
- Infection retardant coatings (IRC) are designed to reduce the risk of PP infection.
Purpose of the Study:
- To compare positive culture rates in patients with and without IRC PPs.
- To analyze changes in bacterial isolates from PPs in patients with overt clinical infection.
- To evaluate the efficacy of IRC PPs in preventing bacterial colonization.
Main Methods:
- Cultures were obtained from PPs during surgical exposure in 236 patients.
- Patients were divided into noninfected (208) and infected (28) groups.
- Subgroups included those with uncoated PPs and IRC PPs; bacterial isolate sensitivity to tetracycline and rifampin was assessed.
Main Results:
- Noninfected patients with IRC PPs had significantly lower positive culture rates (32/75) compared to those with uncoated PPs (85/133) [P=0.0003].
- Staphylococcus genus isolates were less common in noninfected patients with IRC PPs (20/75) versus uncoated PPs (75/133).
- In infected patients, culture rates and Staphylococcus prevalence did not differ significantly between uncoated and IRC PPs.
Conclusions:
- Clinically uninfected PPs can harbor positive bacterial cultures during revision surgery.
- IRC PPs demonstrate a distinct bacterial profile, with a reduction in Staphylococcus genus isolates, even in the absence of overt infection.
- IRC PPs may alter the bacterial colonization patterns on penile prostheses.
Related Concept Videos
01:19Retarders
269
Retarders are chemical admixtures designed to extend the setting time, which is especially useful when there is a delay in sequential concrete pours to prevent cold joints and to achieve a cohesive structure. Retarders, when used in appropriate amounts, can also enhance the architectural appearance of exposed aggregate finishes.
The function of retarders is to delay the setting of concrete, and this effect can be measured using a penetration test. The retardation process involves adding...
The function of retarders is to delay the setting of concrete, and this effect can be measured using a penetration test. The retardation process involves adding...
269
01:19Impact of Groups on Groups
255
Social psychologists analyze how groups influence one another, shaping social structures and interactions through both cooperation and competition. These dynamics manifest in various ways, ranging from economic partnerships to intergroup conflicts that shape societal structures and perceptions.Cooperation and Competition in Intergroup RelationsIntergroup relationships vary across contexts, sometimes fostering cooperation and mutual benefit while at other times leading to conflict and...
255
01:30Impact
509
Impact occurs when two bodies collide, leading to the application of impulsive forces between them. Analyzing impact mechanics involves considering two colliding particles moving along a line known as the line of impact, which passes through their centers and is perpendicular to the contact plane.
When particles with different initial velocities collide, they induce deformation by applying equal and opposite impulses. At the point of maximum deformation, the particles move together with...
When particles with different initial velocities collide, they induce deformation by applying equal and opposite impulses. At the point of maximum deformation, the particles move together with...
509
01:32Pinching-off of Coated Vesicles
4.2K
Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
4.2K
01:33Bacterial Transformation
60.1K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
60.1K
01:12Clathrin Coated Vesicles
9.4K
Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
9.4K