Simultaneous two drugs release form Janus particles prepared via polymerization-induced phase separation approach
Elham Dehghani1, Mehdi Salami-Kalajahi1, Hossein Roghani-Mamaqani1
1Department of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran; Institute of Polymeric Materials, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran.
Colloids and Surfaces. B, Biointerfaces
|June 13, 2018
Summary
Researchers created Janus particles using seeded polymerization, yielding dumbbell-like and snowman-like morphologies. These particles effectively carried and released ibuprofen and DOX, demonstrating potential for dual-drug delivery systems.
Area of Science:
- Polymer Chemistry
- Materials Science
- Nanotechnology
Background:
- Janus particles offer unique properties for advanced applications.
- Controlled synthesis of Janus particles with specific morphologies is crucial.
- Investigating their potential in simultaneous drug delivery is of significant interest.
Purpose of the Study:
- To synthesize Janus particles with distinct morphologies using seeded polymerization techniques.
- To evaluate the loading capacity and release profiles of ibuprofen and doxorubicin (DOX) from these Janus particles.
- To understand the influence of particle morphology on drug loading and release kinetics.
Main Methods:
- Seeded emulsion polymerization of 2-dimethylaminoethyl methacrylate (DMAEMA) using poly(2-hydroxyethyl methacrylate) (PHEMA) seeds.
- Investigated different feeding strategies (one-together, rest, continuous) and seeded distillation precipitation polymerization (DPP).
- Utilized FE-SEM for morphology analysis and conducted drug loading and release studies under varying conditions.
Main Results:
- Dumbbell-like Janus particles were consistently produced via seeded emulsion polymerization, while snowman-like particles were obtained through seeded DPP.
- Minimizing interfacial free energy and differences in solubility parameters influenced the observed morphologies.
- Dumbbell-like particles exhibited higher ibuprofen loading, whereas snowman-like particles showed greater doxorubicin (DOX) loading.
- DOX release was faster at different pH values, with both morphologies showing similar overall release behaviors.
Conclusions:
- Seeded polymerization methods can yield distinct Janus particle morphologies (dumbbell-like and snowman-like).
- Janus particle morphology influences the preferential loading of different drugs (ibuprofen vs. DOX).
- These Janus particles demonstrate potential as carriers for simultaneous dual-drug delivery with tunable release characteristics.
Keywords:
DOXDumbbell-like particlesIbuprofenJanus particlesSimultaneous two drugs releaseSnowman-like particlesMore Related Videos
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