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Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip
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Cross-sectional and longitudinal associations between serum uric acid and endothelial function in subjects with

Atsushi Tanaka1, Atsushi Kawaguchi2, Hirofumi Tomiyama3

  • 1Department of Cardiovascular Medicine, Saga University, Saga, Japan.

International Journal of Cardiology
|June 14, 2018
PubMed

Insights

Lower serum uric acid (SUA) levels correlate with improved vascular health in hypertensive patients, particularly women. SUA may serve as a potential marker for the continuum of hypertension-related vascular dysfunction.

Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Vascular Biology

Background:

  • The continuum of endothelial dysfunction, arterial stiffness, and atherosclerosis is central to hypertension's pathophysiology.
  • Understanding factors influencing this continuum is crucial for managing hypertensive cardiovascular risk.

Purpose of the Study:

  • To examine the cross-sectional relationship between serum uric acid (SUA) and vascular markers in hypertension.
  • To assess the longitudinal association between SUA and endothelial function over time.

Main Methods:

  • Evaluated 648 hypertensive patients on antihypertensive treatment.
  • Measured baseline SUA, flow-mediated vasodilatation (FMD), brachial-ankle pulse wave velocity (baPWV), and carotid intima-media thickness (CCA-IMT).
  • Assessed longitudinal changes in FMD at 1.5 and 3 years relative to baseline SUA.

Main Results:

  • Baseline SUA showed modest correlations with FMD, baPWV, and CCA-IMT, with varying associations by sex and SUA levels.
  • In females, baseline SUA significantly predicted FMD at 1.5 years and, at higher levels (>237.92 μmol/L), independently predicted FMD at 3 years.
  • Longitudinal associations between SUA and FMD were less evident in males.

Conclusions:

  • Lower serum uric acid levels are linked to better vascular markers in the hypertension continuum, especially in females.
  • Serum uric acid demonstrates a longitudinal association with endothelial function, suggesting its potential as a marker for vascular continuum in hypertension.
Abstract

Keywords:
AtherosclerosisEndothelial functionFlow-mediated vasodilatationUric acidVascular function

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