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Updated: Feb 9, 2026
07:14
Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay
Published on: June 16, 2023
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CGRP in Human Models of Migraine
Håkan Ashina1, Henrik Winther Schytz2, Messoud Ashina2
1Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. ashina@dadlnet.dk.
Handbook of Experimental Pharmacology
|June 14, 2018
Summary
Calcitonin gene-related peptide (CGRP) infusion can trigger migraine attacks in some patients, highlighting its role in migraine pathogenesis. Research indicates CGRP may affect blood vessels, nerve activation, and brain structures, influencing migraine development.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Calcitonin gene-related peptide (CGRP) is increasingly recognized for its significant role in migraine pathophysiology.
- Previous studies demonstrate intravenous CGRP infusion can provoke migraine-like attacks in susceptible individuals.
Purpose of the Study:
- To explore the mechanisms by which CGRP induces migraine-like attacks in human models.
- To identify potential sites of CGRP action within the trigeminovascular system and central nervous system.
Main Methods:
- Utilizing provocation experiments with intravenous CGRP infusion in patients with and without aura.
- Analyzing the heterogeneous responses observed in migraine patients following CGRP administration.
Main Results:
- Intravenous CGRP infusion successfully induced migraine-like attacks in a subset of migraine patients, indicating a variable response.
- Identified three primary mechanisms for CGRP-induced migraine: vasodilation (via cAMP/cGMP), trigeminal sensory afferent activation, and modulation of deep brain structures.
Conclusions:
- CGRP plays a critical role in migraine pathogenesis through multiple pathways.
- Further experimental studies are essential to fully elucidate the complex mechanisms of CGRP in migraine.
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