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Vaccinations

Vaccinations

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Related Experiment Video

Updated: Feb 9, 2026

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

Published on: August 1, 2013

Vaccine Development for Cytomegalovirus.

Naoki Inoue¹, Mao Abe², Ryo Kobayashi²

¹Microbiology and Immunology, Gifu Pharmaceutical University, Gifu, Japan. inoue@gifu-pu.ac.jp.

Advances in Experimental Medicine and Biology

|June 14, 2018

Summary

Developing a cytomegalovirus (CMV) vaccine is crucial for public health. Despite challenges like immune evasion and unclear protection correlates, new vaccine candidates show promise.

Keywords:

Animal model Attenuated vaccines Congenital infection Epitope-based vaccines Immune correlates Neutralizing antibodies Pentameric complex Vectored vaccines gB

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Last Updated: Feb 9, 2026

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

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Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

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Expression and Purification of Virus-like Particles for Vaccination

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

Area of Science:

Virology
Immunology
Vaccinology

Background:

Cytomegalovirus (CMV) infection poses significant public health challenges.
A CMV vaccine is a high priority due to potential cost-effectiveness and health benefits.

Purpose of the Study:

To review the challenges and progress in CMV vaccine development.
To discuss various CMV vaccine candidates, clinical trials, and animal models.

Main Methods:

Review of existing literature on CMV vaccine research.
Analysis of different vaccine platforms including live-attenuated, subunit, DNA, and vectored vaccines.
Discussion of immune correlates for protection and viral immune evasion strategies.

Main Results:

Several CMV vaccine candidates are in development, utilizing diverse platforms.
The pentameric complex is identified as a key neutralization target.
Strategies to overcome viral immune evasion are emerging.

Conclusions:

Despite significant hurdles, advancements in understanding CMV biology and immunology are paving the way for effective vaccine development.
Further research into immune correlates and novel vaccine strategies is essential.