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Atrial involvement in arrhythmogenic right ventricular cardiomyopathy patients referred for ventricular arrhythmias

Lingmin Wu1, Jingru Bao1, Erpeng Liang1

  • 1Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of China.

Journal of Cardiovascular Electrophysiology
|June 14, 2018
PubMed

Insights

Atrial involvement is common in arrhythmogenic right ventricular cardiomyopathy (ARVC). Tricuspid regurgitation and reduced ejection fraction increase atrial dilation risk, but genotype does not influence atrial changes in ARVC patients.

Area of Science:

  • Cardiology
  • Genetics
  • Electrophysiology

Background:

  • Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable heart muscle disease primarily affecting the ventricles.
  • Atrial involvement in ARVC is not well understood, prompting this investigation into its prevalence and predictors.

Purpose of the Study:

  • To assess the incidence and characteristics of atrial involvement in ARVC patients.
  • To investigate the role of genotype in ARVC-related atrial disease.
  • To identify predictors of atrial dilation and arrhythmias in ARVC.

Main Methods:

  • Screening of nine known ARVC-causing genes in affected individuals.
  • Assessment of atrial dilation (right and left atria) and atrial tachyarrhythmias (ATa).
  • Correlation analysis between genotype, clinical factors (tricuspid regurgitation, LVEF), and atrial involvement.

Main Results:

  • Atrial involvement, including right atrium (RA) dilation (45%) and left atrium (LA) dilation (16%), was frequent.
  • Mutation carriers showed increased RA dilation (54.7%) compared to non-carriers (27.8%).
  • Tricuspid regurgitation and decreased left ventricular ejection fraction (LVEF) were significant predictors of atrial dilation, while genotype did not show a significant association.

Conclusions:

  • Atrial involvement is a common finding in ARVC.
  • Clinical factors like tricuspid regurgitation and reduced LVEF, rather than genotype, are associated with atrial dilation.
  • Atrial involvement did not significantly impact long-term survival in this ARVC cohort.
Abstract

Keywords:
arrhythmogenic right ventricular cardiomyopathyatrial fibrillationatrial fluttergenotype

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