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Related Concept Videos

Potential Energy00:52

Potential Energy

42.7K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.7K
Potential Energy01:09

Potential Energy

1.0K
A conservative force, such as a gravitational or elastic force, gives the body the capacity to do work. This capacity, measured as the potential energy, depends on the body's location or “position” relative to a fixed reference position or datum. The gravitational potential energy is considered zero at the reference point. Suppose a body is located at some vertical distance above a fixed horizontal reference or datum. In that case, the weight of the body has positive gravitational potential...
1.0K
Subviral Agents01:29

Subviral Agents

580
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
580
Standard Electrode Potentials03:02

Standard Electrode Potentials

50.4K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.4K
Cell Potential and Free Energy02:58

Cell Potential and Free Energy

46.6K
Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
46.6K
The Resting Membrane Potential01:21

The Resting Membrane Potential

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Overview
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Related Experiment Video

Updated: Feb 9, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
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The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

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BPC157 as Potential Agent Rescuing from Cancer Cachexia.

Eun A Kang1, Young-Min Han1, Jeong Min An1

  • 1CHA University School of Medicine, CHA Cancer Prevention Research Center, CHA Bio Complex, Pangyo, Korea.

Current Pharmaceutical Design
|June 15, 2018
PubMed
Summary
This summary is machine-generated.

Cancer cachexia causes severe weight loss and muscle atrophy. This review explores BPC157, a potential therapeutic agent, for treating cancer cachexia, addressing an urgent unmet medical need.

Keywords:
BPC157Cancer cachexiacytoprotectionhypercatabolismhypoanabolismmuscle atrophy.

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Area of Science:

  • Oncology
  • Metabolic Syndromes
  • Gastroenterology

Background:

  • Cancer cachexia is a prevalent metabolic syndrome in terminal cancer patients, characterized by significant weight loss, skeletal muscle atrophy, and fat loss.
  • It contributes to up to 20% of cancer deaths, highlighting an urgent unmet medical need for effective treatments.
  • Current therapeutic strategies, including nutritional support, anti-inflammatory agents, and exercise, have shown limited efficacy.

Purpose of the Study:

  • To review the potential of BPC157, a cytoprotective agent from gastric juices, as a novel therapeutic for cancer cachexia.
  • To present evidence supporting BPC157's efficacy in rescuing cachectic phenotypes.
  • To explore the underlying mechanisms of action for BPC157 in combating cancer cachexia.

Main Methods:

  • Review of existing preclinical and clinical evidence on BPC157.
  • Analysis of molecular mechanisms involved in cancer cachexia.
  • Exploration of BPC157's cytoprotective and anti-cachectic properties.

Main Results:

  • BPC157 has demonstrated potential in preclinical models to mitigate cancer cachexia.
  • Evidence suggests BPC157 can counteract key pathological features of cachexia, such as muscle atrophy and weight loss.
  • The explored modes of action indicate BPC157 may target central nervous system and inflammation-related pathways.

Conclusions:

  • BPC157 shows promise as a novel therapeutic agent for cancer cachexia.
  • Further clinical investigation is warranted to establish BPC157's safety and efficacy in human patients.
  • Combination therapies involving BPC157 may offer a new era in managing cancer cachexia.