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Clinical and molecular markers in COPD.

I Gonçalves¹, M J Guimarães², M van Zeller³

¹Pulmonology Department, Hospital Santa Marta, Lisboa, Portugal.

|June 15, 2018

Summary

Identifying reliable biomarkers for chronic obstructive pulmonary disease (COPD) remains a challenge. Future research aims to combine clinical markers, genetic information, and phenotypes for personalized COPD treatment and precision medicine.

Keywords:

Biomarkers COPD Markers Precision medicine Treatable traits

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Area of Science:

Pulmonary Medicine
Biomarker Research
Personalized Medicine

Background:

Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous condition requiring better assessment and risk prediction tools.
Current GOLD guidelines lack validated biomarkers for stable COPD, despite proposed clinical and molecular markers.
Existing markers have yielded inconsistent results, limiting their clinical utility for prognosis and treatment.

Purpose of the Study:

To critically review established and emerging markers and biomarkers for COPD.
To explore future approaches toward precision medicine in COPD management.
To highlight the need for identifying treatable traits for personalized COPD therapy.

Main Methods:

Literature review of clinical markers, composite scores, and molecular biomarkers in COPD.
Analysis of current trends shifting towards individualized patient treatment.
Examination of the potential for combining various markers for personalized therapy.

Main Results:

No single clinically useful biomarker for stable COPD is currently identified per GOLD guidelines.
Numerous markers (symptoms, function tests, imaging, molecular) have been proposed but with inconsistent results.
A shift towards personalized medicine necessitates identifying treatable traits and marker combinations.

Conclusions:

Validated biomarkers for COPD patient assessment, risk prediction, and treatment guidance are still needed.
Personalized medicine in COPD requires integrating clinical markers, biomarkers, genetics, and phenotypes.
Future COPD management will likely focus on identifying treatable traits for tailored therapeutic strategies.