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Gastrointestinal Motility Disorders01:20

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Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
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The gastrointestinal (GI) tract, extending from the mouth to the anus, plays a pivotal role in the digestion and absorption of nutrients. This process involves both mechanical and chemical actions facilitated by various enzymes.
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The gastrointestinal elimination process involves a complex interplay of neural and hormonal mechanisms that coordinate the final waste removal from the body. This intricate operation encompasses the absorption of water and electrolytes, vital for transforming the remaining indigestible food matter into feces. The large intestine is pivotal in water and electrolyte absorption, forming feces from unabsorbed minerals, undigested food, bacteria, bile pigments, and shed epithelial cells. Essential...
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Proteus spp. as Putative Gastrointestinal Pathogens.

Amy L Hamilton1,2, Michael A Kamm3,2, Siew C Ng4

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|June 15, 2018
PubMed
Summary
This summary is machine-generated.

Proteus bacteria, typically gut commensals, are increasingly recognized as potential pathogens. Their virulence factors suggest a significant role in gastrointestinal diseases, including Crohn's disease.

Keywords:
Crohn's diseaseEnterobacteriaceaeProteusbacteriologygastrointestinal diseaseinfectionsinflammatory bowel disease

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Pathogen Research

Background:

  • Proteus species are Enterobacteriaceae, commonly causing urinary tract infections.
  • They are generally considered gut commensals but are emerging as potential pathogens.

Purpose of the Study:

  • To investigate the pathogenic potential of Proteus species in the gastrointestinal tract.
  • To examine the association between Proteus species and Crohn's disease recurrence.

Main Methods:

  • Review of existing literature on Proteus virulence factors and gastrointestinal associations.
  • Analysis of clinical data linking Proteus to various gastrointestinal conditions.

Main Results:

  • Proteus species possess key virulence factors like motility, adherence, urease, hemolysins, and IgA proteases.
  • Associations found with gastroenteritis, nosocomial infections, appendicitis, and device colonization.
  • A particularly strong link was observed between Proteus species and Crohn's disease recurrence.

Conclusions:

  • Proteus species, despite being low-abundance gut commensals, harbor significant pathogenic potential.
  • Further research is warranted to elucidate their precise role in gastrointestinal diseases, especially Crohn's disease.