Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nature and Nurture01:10

Nature and Nurture

22.4K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

IgA is necessary and sufficient to prevent norovirus infection in mice.

Science translational medicine·2026
Same journal

Human donor liver viability evaluation with polarization-sensitive optical coherence tomography.

Science translational medicine·2026
Same journal

<i>Kbtbd13</i> knockdown restores muscle function in a clinically relevant mouse model of nemaline myopathy type 6.

Science translational medicine·2026
Same journal

AI-CURA, an automated LLM workflow for high-accuracy genetic variant classification.

Science translational medicine·2026
Same journal

Transferrin in combination with induction chemotherapy improves outcomes in mouse models of acute myeloid leukemia.

Science translational medicine·2026
Same journal

<i>SPP1</i><sup>hi</sup> macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium.

Science translational medicine·2026
See all related articles

Related Experiment Video

Updated: Feb 9, 2026

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
06:44

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview

Published on: May 28, 2007

8.0K

Curbing cholera.

Robert H Hall1

  • 1National Institute of Allergy and Infectious Diseases, U.S. National Institutes of Health, Bethesda, MD 20892, USA.

Science Translational Medicine
|June 15, 2018
PubMed
Summary
This summary is machine-generated.

A live cholera vaccine and Lactococcus lactis suppress gut colonization by virulent Vibrio cholerae. This probiotic-like activity was observed in two distinct animal models, offering potential new strategies for cholera prevention.

More Related Videos

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model
08:03

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model

Published on: July 12, 2018

8.9K
Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates
07:58

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates

Published on: May 30, 2017

11.5K

Related Experiment Videos

Last Updated: Feb 9, 2026

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
06:44

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview

Published on: May 28, 2007

8.0K
Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model
08:03

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model

Published on: July 12, 2018

8.9K
Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates
07:58

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates

Published on: May 30, 2017

11.5K

Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Gut colonization by virulent Vibrio cholerae is a primary cause of cholera.
  • Developing effective strategies to prevent Vibrio cholerae colonization is crucial for public health.

Purpose of the Study:

  • To investigate the probiotic-like activity of a live cholera vaccine candidate.
  • To evaluate the efficacy of Lactococcus lactis in suppressing Vibrio cholerae gut colonization.
  • To assess these effects in relevant animal models.

Main Methods:

  • Utilized two distinct animal models to study gut colonization dynamics.
  • Administered a live cholera vaccine candidate and Lactococcus lactis.
  • Assessed the suppression of virulent Vibrio cholerae colonization.

Main Results:

  • Both the live cholera vaccine candidate and Lactococcus lactis demonstrated significant suppression of virulent Vibrio cholerae colonization.
  • The observed effects were consistent across the two animal models studied.

Conclusions:

  • Probiotic-like activity from a live cholera vaccine candidate and Lactococcus lactis can effectively inhibit Vibrio cholerae gut colonization.
  • These findings suggest potential for novel prophylactic approaches against cholera using live vaccines and specific probiotics.