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Updated: Feb 9, 2026
05:30
Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
29.7K
Hand Motor Recovery Following Extensive Frontoparietal Cortical Injury Is Accompanied by Upregulated Corticoreticular
Warren G Darling1, Jizhi Ge2, Kimberly S Stilwell-Morecraft2
1Department of Health and Human Physiology, Motor Control Laboratories.
Summary
Motor recovery after sensorimotor cortex injury is linked to increased corticoreticular projection (CRP) strength. This enhanced CRP from the medial motor cortex (M2) may compensate for brain damage, aiding arm and hand function recovery.
Area of Science:
- Neuroscience
- Motor Control
- Neuroplasticity
Background:
- Arm/hand motor recovery after sensorimotor cortex injury is variable.
- Previous studies linked recovery to corticospinal projection (CSP) strength, but this doesn't explain all cases.
- Lateral sensorimotor cortex injury can decrease medial motor cortex CSP strength, necessitating alternative recovery mechanisms.
Purpose of the Study:
- To test if arm/hand motor recovery after lateral sensorimotor cortex injury involves increased corticoreticular projection (CRP) strength.
- To investigate the relationship between CRP strength and motor function recovery in rhesus monkeys with specific brain lesions.
- To explore the role of the supplementary motor cortex (M2) to gigantocellular reticular nucleus (Gi) pathway in motor recovery.
Main Methods:
- Lesions were created in the primary motor cortex (M1), lateral premotor cortex (LPMC), and sensorimotor cortex of rhesus monkeys.
- Corticoreticular projection (CRP) strength was quantified by injecting anterograde tracers into M2 and using stereology to count synaptic boutons in the gigantocellular reticular nucleus (Gi).
- Motor function recovery was assessed, and correlated with CRP bouton counts.
Main Results:
- Monkeys with larger sensorimotor cortex lesions (F2P2 group) showed significantly higher CRP bouton numbers in the Gi compared to controls and F2 lesion groups (p=0.0002).
- Recovery of reaching and fine hand/digit function in the F2P2 group strongly correlated with increased CRP bouton numbers.
- These findings contrast with previous observations of decreased M2-CSP strength in F2P2 cases, highlighting CRP as a potential compensatory pathway.
Conclusions:
- Upregulation of the M2 corticoreticular projection (CRP) is a key mechanism for arm/hand motor recovery following extensive frontoparietal sensorimotor cortex injury.
- The enhanced M2-CRP pathway may influence reticulospinal tract function, contributing to motor recovery.
- This study identifies a novel compensatory pathway involved in motor recovery, distinct from the corticospinal tract.
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