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Immunotherapy Resistance by Inflammation-Induced Dedifferentiation.
Arnav Mehta1,2, Yeon Joo Kim1, Lidia Robert1
1Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.
Cancer Discovery
|June 15, 2018
Summary
Metastatic melanoma can resist adoptive T-cell transfer therapy (ACT) by dedifferentiating, losing antigen expression. This inflammation-induced dedifferentiation was observed in a patient and replicated in cell lines, suggesting new therapeutic strategies.
Area of Science:
- Oncology
- Immunology
- Dermatology
Background:
- Recent advances in targeted therapy and immunotherapy have improved metastatic melanoma treatment.
- Tumor-acquired resistance remains a significant challenge in effective cancer immunotherapy.
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