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Updated: Feb 9, 2026

Author Spotlight: Advancing 3D Coculture Systems with PVA-PCL Nanofibrous Membranes
Published on: December 27, 2024
Functionalized Electrospun Poly(Vinyl Alcohol) Nanofibrous Membranes with Poly(Methyl Vinyl Ether-Alt-Maleic
Mesbah Najafi1, Joronia Chery2, Margaret M Frey3
1Department of Fiber Science & Apparel Design, Cornell University, Ithaca, NY 14853, USA. mn574@cornell.edu.
Abstract:
In this work, electrospun poly(vinyl alcohol) (PVA) nanofiber membranes were functionalized by incorporating poly(methyl vinyl ether-alt-maleic anhydride) (poly(MVE/MA), PMA) for the selective adsorption of proteins. The capture performance was regulated by an optimizing buffer pH, PMA content, and protein concentration. Lysozyme was used as the model protein and a high adsorption capacity of 476.53 ± 19.48 was obtained at pH 6, owing to the electrostatic attraction between the negatively charged nanofibers and positively charged proteins. The large specific surface area, highly open porous structure, and abundant available carboxyl groups contributed to such high adsorption performance. Moreover, the nanofiber membranes exhibited good reusability and good selectivity for positively charged proteins. The obtained results can provide a promising method for the purification of proteins in small analytic devices.
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