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Updated: Feb 9, 2026

Forward Genetic Approaches in Chlamydia trachomatis
Published on: October 23, 2013
Lysine acetylation of major Chlamydia trachomatis antigens
Jelena Mihailovic1, Aleksandra Inic-Kanada2, Katarina Smiljanic1
1Center of Excellence for Molecular Food Sciences and Department of Biochemistry, University of BelgradeFaculty of Chemistry, Belgrade, Serbia.
Abstract:
Chlamydia trachomatis (Ct) is a human pathogen causing trachoma and infertility. We investigated acetylation at lysine residues of chlamydial antigenic proteins: major outer membrane protein (MOMP), 60 kDa chaperonin (chlamydial Hsp60), elongation factor G (EF-G), enolase and the polymorphic membrane proteins PmpB, PmpE and PmpF. 60 kDa chaperonin, EF-G and PmpB showed the highest degree of acetylation. Our data show that important Ct antigens could be post-translationally modified by acetylation of lysine residues at multiple sites. Further studies are needed to investigate total acetylome of Ct and the impact PTMs might have on Ct biology and pathogenicity.
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