Related Experiment Video

Updated: Feb 9, 2026

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
14:40

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Published on: March 5, 2022

3.8K

Epitranscriptomics of cancer

Marina Tusup1, Thomas Kundig1, Steve Pascolo1

  • 1Department of Dermatology, University Hospital of Zürich, Zurich 8091, Switzerland.

World Journal of Clinical Oncology
|June 15, 2018
PubMed

Insights

RNA modifications like N6-Methyladenosine play a dual role in cancer, promoting or inhibiting tumor growth. Understanding these dynamic changes offers potential new cancer treatment strategies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Epigenetics

Background:

  • Cellular RNA modifications are crucial for gene expression regulation.
  • The impact of these modifications on cancer development is an emerging area of research.
  • Diverse and often opposing roles of RNA modifications in cancer progression have been observed.

Purpose of the Study:

  • To review the current understanding of key RNA modifications in cancer.
  • To explore the potential impacts of N6-Methyladenosine, Pseudouridine, Inosine, 2'O-methylation, and methylcytidine on cancer.
  • To identify research gaps and potential therapeutic strategies targeting RNA modifications.

Main Methods:

  • Literature review of current research on RNA modifications and cancer.
  • Analysis of studies investigating the functional roles of specific RNA modifications.
  • Synthesis of findings on the pro- or anti-tumorigenic effects of RNA modifications.

Main Results:

  • N6-Methyladenosine, Pseudouridine, Inosine, 2'O-methylation, and methylcytidine exhibit varied effects on cancer growth and invasiveness.
  • Some modifications enhance cancer progression, while others suppress it.
  • Evidence suggests RNA modifications are critical players in oncogenesis.

Conclusions:

  • Dynamic RNA modifications represent a promising frontier for novel cancer therapies.
  • Modulating RNA modification patterns could offer a new therapeutic approach to cancer treatment.
  • Further research is needed to fully elucidate the complex roles of RNA modifications in cancer.
Keywords:
2’O-methylation or methylcytidine5-methylcytidineInosineN6-methyladenosinePseudouridineRNA modifications

More Related Videos

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.6K
Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

18.9K

Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.4K
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.5K
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.2K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.1K
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.9K