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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Epitranscriptomics of cancer.

Marina Tusup1, Thomas Kundig1, Steve Pascolo1

  • 1Department of Dermatology, University Hospital of Zürich, Zurich 8091, Switzerland.

World Journal of Clinical Oncology
|June 15, 2018
PubMed
Summary
This summary is machine-generated.

RNA modifications like N6-Methyladenosine play a dual role in cancer, promoting or inhibiting tumor growth. Understanding these dynamic changes offers potential new cancer treatment strategies.

Keywords:
2’O-methylation or methylcytidine5-methylcytidineInosineN6-methyladenosinePseudouridineRNA modifications

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Area of Science:

  • Molecular Biology
  • Oncology
  • Epigenetics

Background:

  • Cellular RNA modifications are crucial for gene expression regulation.
  • The impact of these modifications on cancer development is an emerging area of research.
  • Diverse and often opposing roles of RNA modifications in cancer progression have been observed.

Purpose of the Study:

  • To review the current understanding of key RNA modifications in cancer.
  • To explore the potential impacts of N6-Methyladenosine, Pseudouridine, Inosine, 2'O-methylation, and methylcytidine on cancer.
  • To identify research gaps and potential therapeutic strategies targeting RNA modifications.

Main Methods:

  • Literature review of current research on RNA modifications and cancer.
  • Analysis of studies investigating the functional roles of specific RNA modifications.
  • Synthesis of findings on the pro- or anti-tumorigenic effects of RNA modifications.

Main Results:

  • N6-Methyladenosine, Pseudouridine, Inosine, 2'O-methylation, and methylcytidine exhibit varied effects on cancer growth and invasiveness.
  • Some modifications enhance cancer progression, while others suppress it.
  • Evidence suggests RNA modifications are critical players in oncogenesis.

Conclusions:

  • Dynamic RNA modifications represent a promising frontier for novel cancer therapies.
  • Modulating RNA modification patterns could offer a new therapeutic approach to cancer treatment.
  • Further research is needed to fully elucidate the complex roles of RNA modifications in cancer.