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Related Experiment Videos

Marijuana use does not spuriously elevate serum human chorionic gonadotropin levels.

G D Braunstein, R Thompson, S Gross

    Urology
    |June 1, 1985
    PubMed
    Summary

    Marijuana use does not appear to falsely elevate human chorionic gonadotropin (HCG) levels. This study found no detectable HCG in marijuana users, refuting previous claims of spurious elevation in testicular cancer patients.

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    Area of Science:

    • Oncology
    • Toxicology
    • Endocrinology

    Background:

    • Previous reports suggested marijuana use may falsely elevate human chorionic gonadotropin (HCG) levels.
    • This spurious elevation was particularly noted in patients with testicular germ cell tumors.
    • The potential impact of delta 9-tetrahydrocannabinol (delta 9-THC) on HCG assays requires clarification.

    Purpose of the Study:

    • To investigate the association between marijuana use and serum HCG levels.
    • To determine if delta 9-THC interferes with HCG radioimmunoassays.
    • To confirm or refute the claim of marijuana-induced spurious HCG elevation.

    Main Methods:

    • Serum samples from 16 men, categorized by marijuana use (delta 9-THC presence/absence), were analyzed.
    • Serum HCG and delta 9-THC levels were measured.

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  • In vitro experiments tested the effect of delta 9-THC on HCG radioimmunoassay using pooled male serum.

    • Main Results:

    • None of the serum samples from marijuana users (with detectable delta 9-THC) showed immunoreactive HCG.
    • No HCG was detected in samples from non-users either.
    • Direct addition of delta 9-THC to male serum did not affect the HCG radioimmunoassay results.

    Conclusions:

    • Marijuana use does not appear to cause a spurious elevation of serum HCG.
    • The findings contradict earlier reports suggesting a link between marijuana and false-positive HCG results.
    • This study provides evidence against delta 9-THC interference in HCG detection assays.