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Human papillomavirus type 16 DNA sequence.

K Seedorf, G Krämmer, M Dürst

    Virology
    |August 1, 1985
    PubMed
    Summary
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    The complete nucleotide sequence of human papillomavirus type 16 (HPV16) DNA was determined from cervical cancer. Its genetic organization is similar to other papillomaviruses, with an interrupted E1 protein reading frame.

    Area of Science:

    • Molecular Biology
    • Virology
    • Genomics

    Background:

    • Human papillomavirus type 16 (HPV16) is a significant cause of invasive cervical carcinoma.
    • Understanding the complete genome sequence of HPV16 is crucial for comprehending its oncogenic mechanisms.

    Purpose of the Study:

    • To determine the complete nucleotide sequence of HPV16 DNA.
    • To compare the HPV16 genome organization with other sequenced papillomaviruses.

    Main Methods:

    • Cloning of HPV16 DNA from an invasive cervical carcinoma.
    • Determination of the complete nucleotide sequence (7904 bp).
    • Homology comparisons of open reading frames with other papillomavirus sequences.

    Main Results:

    Related Experiment Videos

  • The complete nucleotide sequence of HPV16 DNA was successfully determined.
  • Major open reading frames were aligned with other published papillomavirus DNA sequences.
  • The general organization of HPV16 open reading frames is similar to BPV1, HPV1a, HPV6b, and CRPV.

    • Conclusions:

    • The genomic organization of HPV16 is conserved among papillomaviruses.
    • An interruption in the reading frame for a suspected E1 protein was identified in the HPV16 sequence.