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Analysis of trace elements in the human labyrinth by using proton microprobe
Acta Oto-Laryngologica
|March 1, 1985
Summary
Zinc concentration in the spiral tract increases with age, accumulating from the bone surface inward. Conversely, calcium levels decline with aging, confirming prior histological and densitometric studies.
Area of Science:
- Otolaryngology
- Biochemistry
- Aging Research
Background:
- The spiral tract's mineral composition and its changes with age are not fully understood.
- Previous histological, densitometric, and macroscopical studies suggested age-related alterations in this region.
Purpose of the Study:
- To investigate the age-dependent concentration of zinc and calcium in the spiral tract.
- To correlate these findings with previous investigations of the internal auditory meatus.
Main Methods:
- Analysis of zinc and calcium concentrations within the spiral tract.
- Correlation of mineral concentrations with subject age.
Main Results:
- Zinc concentration in the spiral tract demonstrates a clear age dependency.
- Zinc accumulation progresses from the bone surface towards the basal coil of the cochlea with advancing age.
- Calcium concentration exhibits a decrease in correlation with increasing age.
Conclusions:
- The study confirms age-related changes in spiral tract mineral composition.
- Findings support previous histological and densitometric evidence regarding age-dependent alterations in the internal auditory meatus.