Related Experiment Video
Updated: Feb 9, 2026
14:14
Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
Published on: December 11, 2017
14.7K
On-X mitral valve replacement: a single-centre experience in 318 patients
Giacomo Murana1, Jacopo Alfonsi1, Carlo Savini1
1Department of Cardiothoracic Surgery, S. Orsola Hospital, University of Bologna, Bologna, Italy.
Interactive Cardiovascular and Thoracic Surgery
|June 15, 2018
Summary
Mitral valve replacement with the On-X prosthesis shows favorable early and late outcomes. This latest generation valve offers safe long-term durability with a low incidence of thromboembolism for mitral valve disease patients.
Area of Science:
- Cardiovascular Surgery
- Prosthetic Heart Valves
- Cardiac Surgery Outcomes
Background:
- Mitral valve replacement is the only option when mitral valve repair is not feasible.
- The On-X mitral valve is a latest-generation prosthesis for mitral valve replacement.
Purpose of the Study:
- To investigate the early and late outcomes of mitral valve replacement using the On-X prosthesis.
- To assess the safety and durability of the On-X mitral valve in a clinical setting.
Main Methods:
- Retrospective analysis of 318 consecutive patients undergoing mitral valve replacement with the On-X prosthesis between 1998 and 2016.
- Exclusion of patients with combined aortic procedures.
- Mean follow-up of 5.6 years, including assessment of survival, reoperation, and thromboembolic/hemorrhagic events.
Main Results:
- Overall hospital mortality was 4.4%. Survival rates at 10 years were 70.9%.
- Predictors of late mortality included hypertension, COPD, and chronic renal failure.
- Freedom from reoperation at 10 years was 92.5%. Freedom from thromboembolic or hemorrhagic events at 10 years was 89.0%.
Conclusions:
- The On-X valve demonstrates effective performance in mitral valve diseases of various etiologies, including unfavorable anatomies.
- The prosthesis ensures safe long-term durability with a low rate of thromboembolic complications.
More Related Videos
Related Concept Videos
01:27Mitral Valve Prolapse I: Introduction
570
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
570
01:22Mitral Valve Prolapse II: Assessment and Management
630
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
630
01:19Mitral Valve Prolapse III: Nursing Management
395
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
395
01:16Heart Valves
12.2K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
12.2K
01:22Mitral Stenosis I: Introduction
700
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
700
01:20Mitral Regurgitation I: Introduction
601
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
601