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Updated: Feb 9, 2026

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats
Published on: October 24, 2016
Mast cell and plasma cell collision tumor in the spleen of a dog
Valarie A Pallatto1, Molly A Bechtold2
1ANTECH Diagnostics, Cary, NC, USA.
Abstract:
A 9-year-old spayed female English Mastiff was referred for outpatient ultrasound due to a 3-week history of weight loss, vomiting, and decreased appetite. Abdominal ultrasound showed multiple splenic masses of varying sizes and serum chemistry panel showed hyperglobulinemia. Cytologic examination of fine-needle aspirates of the splenic masses indicated a mast cell and plasma cell collision tumor. Results of serum and urine protein electrophoresis and immunofixation indicated the plasma cell neoplasia was producing IgA immunoglobulins.
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