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Related Experiment Video

Updated: Feb 9, 2026

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pH-Responsive hyaluronated liposomes for docetaxel delivery.

Jae Min Lee1, Hongsuk Park2, Kyung Taek Oh3

  • 1Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Bucheon-si, Gyeonggi-do 14662, Republic of Korea.

International Journal of Pharmaceutics
|June 15, 2018
PubMed
Summary

This study developed pH-responsive liposomes using hyaluronic acid-grafted polymer for targeted docetaxel delivery. These liposomes efficiently release the drug in acidic tumor environments and show potential for colon cancer therapy.

Keywords:
3-Diethylaminopropyl (DEAP)DocetaxelEndosomal escapeHyaluronic acidpH-Responsive liposome

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Area of Science:

  • Biotechnology
  • Materials Science
  • Oncology

Background:

  • Development of targeted drug delivery systems is crucial for improving cancer therapy efficacy.
  • Liposomes offer a versatile platform for encapsulating chemotherapeutic agents.
  • pH-responsive polymers can enhance drug release at tumor sites.

Purpose of the Study:

  • To create pH-responsive liposomes for targeted delivery of docetaxel (DTX).
  • To investigate the drug release characteristics of these liposomes at endosomal pH.
  • To evaluate the cellular uptake and in vitro cytotoxicity of the liposomes in colon cancer cells.

Main Methods:

  • Preparation of docetaxel-loaded hydrogenated soy phosphatidylcholine (HSPC) liposomes.
  • Decoration of liposomes with hyaluronic acid grafted with 3-diethylaminopropyl (HA-g-DEAP) groups.
  • Assessment of pH-triggered drug release at pH 6.5.
  • Evaluation of cellular uptake in CD44-overexpressing HCT-116 cells.
  • In vitro cytotoxicity testing.

Main Results:

  • Liposomes decorated with HA-g-DEAP demonstrated efficient docetaxel release at pH 6.5.
  • The hyaluronated liposomes showed effective entry into HCT-116 cells.
  • Significant increase in HCT-116 tumor cell death was observed in cytotoxicity tests.

Conclusions:

  • The developed pH-responsive liposomes show promise for targeted tumor therapy.
  • Hyaluronic acid-grafted liposomes facilitate efficient drug release and cellular uptake.
  • These findings highlight the pharmaceutical potential of this novel drug delivery system in oncology.